Demonstration of Distinct Antigenic Profiles of Small B-Cell Lymphomas by Paraffin Section Immunohistochemistry
نویسندگان
چکیده
منابع مشابه
A Practical Guide to Differential Diagnosis of Small B Cell Lymphomas
Correct diagnosis and classification of lymphoid neoplasms depends on the integration of morphologic, immunophenotypic and molecular genetic features. The mature small B cell lymphomas despite their overlapping histomorphologies, have different clinical behavior and treatment. In this review, differentia...
متن کاملThe value of immunohistochemistry on paraffin wax embedded tissue sections in the differentiation of small lymphocytic and mantle cell lymphomas.
AIMS To determine whether immunohistochemistry applied to paraffin wax embedded biopsy tissue can be used to distinguish between B-small lymphocytic lymphoma (B-SLL) and mantle cell lymphoma (MCL). METHODS Formalin fixed, paraffin wax embedded tissue blocks of 12 cases of B-SLL and 12 cases of MCL were retrieved from the files of the Department of Pathology, Southampton University Hospitals T...
متن کاملLymphoma immunophenotyping: a new era in paraffin-section immunohistochemistry.
Recent advances in immunohistochemistry have made it possible to investigate lymphomas for the expression of a wide range of antigens in fixed tissues. Epitope retrieval, sensitive detection methods, and the availability of new monoclonal antibodies have all contributed to one's ability to perform detailed immunophenotyping that previously could only be done in cryostat sections or by flow cyto...
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Two hundred sixteen patients with a nonfollicular small cell lymphoma followed up in our department over a 5-year period have been reviewed to define the clinical behavior and survival of patients with each histologic subtype. The respective frequencies of major subtypes were: small lymphocytic/lymphoplasmacytoid lymphoma (immunocytoma, SL/LPL), 28%; large cell-rich immunocytoma (LCRI), 7%; man...
متن کاملa practical guide to differential diagnosis of small b cell lymphomas
correct diagnosis and classification of lymphoid neoplasms depends on the integration of morphologic, immunophenotypic and molecular genetic features. the mature small b cell lymphomas despite their overlapping histomorphologies, have different clinical behavior and treatment. in this review, differential diagnosis of this category of tumors and a practical approach based on biomarkers evaluati...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 1999
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/112.3.319